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StemRD GDC-0449, SMO antagonist 拮抗劑

簡(jiǎn)要描述：StemRD GDC-0449, SMO antagonist 拮抗劑
規(guī)格型號(hào)：25mg/支

產(chǎn)品型號(hào)：GDC-25
廠商性質(zhì)：代理商
更新時(shí)間：2016-12-28
訪問(wèn) 量：1988

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品牌	StemRD/美國(guó)

StemRD GDC-0449, SMO antagonist 拮抗劑產(chǎn)品英文簡(jiǎn)述:

GDC-0449 （Vismodegib）: A potent antagonist of SMO （smoothened）. This small molecule compound is a hedgehog pathway inhibitor by directly binding to SMO. This molecule has been developed by Genentech for clinical application against hedgehog-dependent cancers.

Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives IC50 of 5-20 nM.

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